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Overall aims:
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Gene Discovery-Assess genomic susceptibility to CaP in African descent populations. This will be accomplished by validating reported CaP susceptibility loci in African descent populations and undertaking large-scale gene discovery efforts in Africans.
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Evolutionary and Population Genomics-Use population methods to understand the large population genetic and CaP risk differences between populations of African and European descent, and to better understand why genome-wide association study loci identified in Caucasian and Asian populations are not usually replicated in African descent populations and to gain a better understanding of the genomic architecture of CaP in African descent populations.
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Tumor Pathology and Biomarkers-Study prostate tumor material to understand the somatic architecture of CaP in African descent populations and evaluate/explain differences in outcome by ethnicity and geography. These biomarkers and clinical data will be used to develop predictor nonograms.
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CaP Progression/Metastasis Risk Evaluation-Examine the association between demographic and lifestyle factors (eg. Obesity, diabetes, physical inactivity) and subsequent risks of CaP progression/metastasis, CaP-specific mortality, and overall mortality in the entire cohort of CaP patients.
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Influence of Diet on CaP Incidence-Evaluate existing dietary data, identifying the main dietary patterns among African men and examine the association between these patterns and prostate cancer risk.
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​Overall aims:
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To Optimize Diagnostic, Monitoring, and Therapeutic Approaches for African and African American Men. We will develop and test innovative rational-based therapies and define new approaches for therapeutic intervention focused specifically at the situation of African and African American men with prostate cancer.
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To Generalize Precision Medicine Approaches to African and African American Men. We will identify critical subtypes and biomarkers of disease progression and response, with the goal of developing metrics for personalized medicine and determining the molecular basis of risk in African American men with prostate cancer.
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To Implement and Disseminate Optimal Therapeutic Approaches to African and African American men with prostate cancer. Planned strategies will encourage and promote the translation of innovative, impactful clinical approaches that can be implemented in communities.
Diet & Nutrition
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​Forum for MADCaP Investigators to meet with experts on Diet & Nutrition in Africa and determine interest in developing a comprehensive instrument for the study, participate in a pilot study to develop and collect data on research questions.
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Tissue Network
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To curate a biorepository of prostate tumor and normal tissues with downstream biosamples that can be used to support current and future research and to undertake translational research using molecular biomarkers to understand aggressive prostate cancer in African descent men.
Prostate Tumor Marker Data Group
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Various investigators from MADCaP US and Africa to collaborate on various projects working with prostate tumor markers including the distribution of various biomarkers amongst men of African descent.
BMI Group
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The BMI Working aims to analyze BMI-related data, contribute to the prostate cancer literature and establish a track record for productive
collaboration within the consortium
Education
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For all educational resources
Survivorship & Outcomes
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To establish a cohort of prostate cancer survival/survivorship with African patients enrolled into U01 MADCaP case-control study Follow-up prostate cancer patients for outcomes after diagnosis: Receipt of cancer treatment Cancer recurrence, progression, and metastasis Overall and cancer-specific mortality
Pathology Page
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Pathological work for MADCaP Africa
and MADCaP US. Includes Round Robin data, IHC data from SCORE statistical analysis, DeepBio collaboration, and the MADCaP Network.
Community Outreach
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The PRECISE initiative is to develop and implement precision prostate cancer screening and disease monitoring practices that will improve clinical outcomes and reduce comorbidities related to overtreatment. A central focus of this work is to ensure all populations benefit and to reduce disparities in prostate cancer mortality.
NAFLD/Metabolomics Group
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The Metabolomics group focuses on characterizing diabetes, pre-diabetes, and NAFLD in African Population.Additionally, the group aims to look at relationships between metabolomics profile and pre-diabetes, diabetes, and non-alcoholic fatty liver disease.